Amazon has been rolling out new AWS regions regularly over the last few quarters. Just this morning they announced a new Sao Paulo region. The great news is that Zencoder already operates in all AWS regions (including Sao Paulo). In your API request you can specify the region you'd like to use. You can use a more general region, like: us, europe, asia, or sa. However, you can also be more specific and target a particular AWS region, like: us-n-virginia, us-oregon, us-n-california, europe-ireland, asia-singapore, asia-tokyo, or sa-saopaulo. Read the region docs for more complete information.